Navegando por Autor "Pereira, Patrícia de Souza Pinto"

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    Influência do uso da pressão positiva nas vias aéreas sobre os índices de rigidez arterial de pacientes com apneia obstrutiva do sono grave
    (Faculdade Ciências Médicas de Minas Gerais, 2020-07-16) Pereira, Patrícia de Souza Pinto; Machado, Maria da Gloria Rodrigues; Silva, José Felippe Pinho da
    Introduction: Obstructive sleep apnea (OSA) and arterial stiffness are associated with an increased risk of cardiovascular morbidity and mortality and worsening patients' quality of life. Studies of the association between reduced arterial stiffness and cardiovascular risk with adherence to treatment with positive airway pressure (PAP) by individuals with OSA are not well established. Objetive: To evaluate the impact of PAP therapy on arterial stiffness, quality of life and sleep in patients diagnosed with severe OSA. Method: 43 patients with OSA participated in this study, being 21 users of PAP (OSA-PAP) and 22 non-users (OSA C). Arterial stiffness was assessed by the brachial oscillometry device and quality of life by the specific Quebec Sleep Questionnaire (QSQ). Results: In this case-control study, pulse wave velocity (PWV) was similar in both groups (9.22 ± 1.52 versus 8.44 ± 1.28, p = 0.090), and augmentation index (AIx @ 75) was significantly higher in the OSA-PAP group (28.95 ± 8.53 versus 21.44 ± 9.46, p = 0.035). In the OSA-PAP group, the multiple regression model identified that the variable, total time of use of PAP explained 45.0% of the AIx @ 75 variability [F (1.17) = 13.898; p <0.001; R²: 0.450. The OSA-PAP group had better cardiac function, evidenced by the greater stroke volume (64.41 ± 12.67 versus 72.83 ± 10.5 ml, p = 0.048) and lower heart rate (75 ± 13 versus 65 ± 12 bpm, p = 0.014). The sub-items of the QSQ questionnaire were similar in both groups. Conclusion: The analysis of the positive effects of PAP should not be limited to the impact of this therapy only on quality of life and peripheral blood pressure. The data reveal that AIx @ 75 can be valuable for assessing the stiffness of a patient with severe OSA whose sample is homogeneous and that PAP improves hemodynamic function independently of arterial stiffness. In addition, the total time of use of PAP is negatively related to AIx @ 75.