2025-11-252025-07-07https://repositorio.cmmg.edu.br/handle/123456789/104Background: The World Health Organization (WHO) proposes, as a public health policy and strategy, the Integrated Care for Older People (ICOPE), based on the concepts of intrinsic capacity (IC) and functional ability in primary care. To date, no studies have been identified investigating the association between arterial stiffness (AS) and changes in the locomotion and cognition domains of IC in older adults. Objectives: To assess whether AS indices are associated with changes in the locomotion and cognition domains proposed by the WHO/IC in older adults in primary care. Methods: This was a cross-sectional study using baseline data from the ICOPE BRAZIL cohort. Older adults (≥60 years) registered in Primary Health Care Units (UBS) were included, except for those unable to travel to the UBS. Vascular, hemodynamic, and AS parameters were assessed by brachial artery oscillometry using the Mobil-O-Graph® (IEM, Stolberg, Germany). Locomotion was assessed using the 4-meter gait speed test (GS4) in meters per second (m/s), and cognition was evaluated using the Mini-Mental State Examination (MMSE). Bivariate regressions were conducted between GS4, MMSE, PWV, and sociodemographic variables using Pearson’s test for continuous variables and biserial correlation for continuous and categorical variables. Structural Equation Modeling via Path Analysis was used to assess the multivariate associations between the variables described above. Results: Ninety-five older adults participated in the study, with a mean age of 68.65 ± 6.44 years [67.00] and mean education of 7.05 ± 4.89 years [5.00]. In bivariate analyses, AS measured by PWV (r = -0.31; p = 0.003) was negatively correlated with cognition (MMSE). Significant correlations with cognition were also observed for age (r = -0.34; p < 0.001) and locomotion (GS4) (r = 0.29; p = 0.005). Locomotion was negatively correlated with body mass index (BMI) (r = -0.25; p = 0.014). Path Analysis showed that age and BMI were directly and significantly associated with PWV (βAge = 0.18, p < 0.001; βBMI = 0.03, p = 0.005; R² = 0.83). Regarding cognition, associations were found with age and PWV (βAge = -0.30, p = 0.045; βPWV = -1.07, p = 0.002; R² = 0.10). For locomotion, associations were observed with BMI, MMSE, and PWV (βBMI = -0.01, p = 0.017; βMMSE = 0.02, p = 0.027; βPWV = -0.06, p = 0.02; R² = 0.15). Conclusion: Associations were found between AS, measured by PWV, and IC (locomotion and cognition) in older adults in primary care. Increased age and BMI significantly impacted PWV, leading to impairments in locomotion and cognition. Early identification of AS changes using a non-invasive, examiner-independent tool in primary care may allow better clinical management and prevent worsening of cardiovascular diseases. Furthermore, it may help detect alterations in locomotion and cognition, thus complementing the WHO/IC/ICOPE framework.Acesso abertoPrimary Health Care; Older Adults; Intrinsic Capacity; Arterial Stiffness.Dissertação4.01.00.00-6 - Medicina